1 Head Office International Labmate Limited. Oak Court Business Centre, Sandridge Park, Porters Wood St Albans, Herts AL3 6PH, UK Tel:+ 44 ( 0) 1727 855574 Fax:+ 44 ( 0) 1727 833014 chromatographytoday@ ilmdesigns. co. uk www. chromatographytoday. com Michael Pattison, Chairman International Labmate Limited. Sales and Marketing Bernie Monaghan, Editor Chromatography Consulting International Tel:+ 44 ( 0) 1695 51973 bm@ chromatographyconsulting. com Chris Jarvis, Guy Whettam, John Hobbs- Morris and Twan Heesakkers International Labmate Sales Team Tel:+ 44 ( 0) 1727 855574 Contributing Editors Dr John Lough President of the Chromatographic Society Reader in Pharmaceutical Analysis University of Sunderland jlough@ sunderland. ac. uk Dr Paul Ferguson Senior Principal Scientist Pfizer Global Research and Development Richard Houghton Principal Scientist Bioanalytical Sciences, Quotient Bioresearch Dr. John Reilly Research Investigator II Novartis Institute of Biomedical Sciences Production Team Helen Sweetland, ILM designs helen@ ilmdesigns. co. uk Gary Durham, Robert Battell, Heather Vincent, Caroline Belt, Matt Cook and Jill Mitchel Published - February/ March, May/ June, August/ September and November/ October Chromatography Today is distributed free of charge to scientists, laboratory technicians and environmentalists throughout the United Kingdom. The publication has the support of leading suppliers of equipment in the region and is displayed at the major exhibitions and conferences in these markets to attract additional readership. Chromatography Today is published with the full support of the Chromatographic Society. If you are not receiving your own copy of Chromatography Today please send us an email with your details to chromatographytoday@ ilmdesigns. co. uk. If you are based outside of the United Kingdom a subscription charge of £ 55.00, £ 71.00 or $ 105.00 would apply. Although every effort is made to ensure the accuracy of the material published, ILM designs and its offices cannot accept responsibility for claims made by contributors, manufacturers or advertisers. © All rights reserved by ILM designs reproduction in part of whole without written permission is strictly prohibited Published with the full support of the Chromatographic Society by International Labmate ( ILM) Printed in the UK by Newnorth Print Ltd Contents 2Foreword by Alan Henly Preparative Chiral Separations - from Laboratory Scale to Production 4 Enabling facile, rapid and successful chromatographic Flash purification 10 Applications of Liquid- Liquid Chromatography Instrumentation for Laboratory Preparative & Process Chemistry 16 Articles ISSN: 1752- 8070 22The Chromatographic Society 2010 48Separation Science / Spectroscopy Meetings Calender 26Lindner receives Martin Medal - finally Valve Innovation Optimises Chromatography Process; Removing Dead Legs, Minimising Hold- Up Volumes & Increasing Yields 30 32The John Dolphin Fellowships Facing the challenges in bio- pharmaceutical production: developments in ion exchange media to bring down cost of goods. 38 The 18th International Reid Bioanalytical Forum 43