20November/ December 2009 Surface dissolution imaging gives insight into bioavailability Paraytec has announced an exciting new tool for surface dissolution imaging. The ActiPix SDI300 provides unique insights into processes taking place microns to millimetres from the surface enabling both erosion and dissolution phenomena to be visualised simultaneously. Initial results indicate that the SDI300 offers intriguing insights for researchers investigating bioavailability and a diverse range of substances including APIs, formulations, gels, liquids, stents and patches. For further information please contact Paraytec on + 44- 1904- 526270 or download the product Literature on http:// www. paraytec. com/ products/ actipix- dissolution- imager/ info@ paraytec. com or + 44 ( 0) 1904 526270 www. paraytec. com ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? Following the launch of the new Valco catalogue, Thames Restekis adding a number of new VICI products to their extensive range of chromatography consumables. These include: 360 micron high pressure fittingswhich allow direct connection of fused silica, PEEK, stainless or electroformed nickel tubing without the use of liners. A one- piece snap fitting nevertheless allows the ferrule to rotate freely as the nut tightens so that the tube doesn't twist. The compact size and fine threads create a leak- free connection that seals at pressures in excess of 20,000 psi and which can be easily formed with the available manual tool. Cheminert UHPLC injector, ideal for current analytical techniques requiring system pressures up to 20,000 psi, this comes in variable port versions, with bores as small as 100 µm. Cheminert Integrated Motor/ Valves for HPLC - this series is an integrated motor/ valve assembly, designed specifically to be built into an OEM system. Using the established injector design and a 24volt motor this is both compact and lightweight and needs only to be connected to the instrument's power supply. Dual Layer PEEK Tubingeliminates contamination issues by pigments used to color code the tubing, as the pigmented layer surrounds a separate but integrally bonded inner layer of natural PEEK. For more information on products or a copy of the catalogue, contact Thames Restek on 01494 563377 or go to www. thamesrestek. co. uk Thames Restek add new VICI Valco products to range Thermo Fisher Scientific ( USA) announce the introduction of a new program that invites scientists to trade in their single quadrupole or ion trap mass spectrometer - from any vendor - and upgrade to a Thermo Scientific linear ion trap technology. For a limited time only, the program will make the most advanced Thermo Scientific instruments accessible to single quadrupole and ion trap users. By trading- in their old single quadrupole or ion trap mass spectrometers, scientists can upgrade the analytical power of their laboratory with the Thermo Scientific LTQ XL or the LTQ Velos T the world's fastest and most sensitive LC- MS ion trap, or receive up to 30 percent off the price of a new Thermo Scientific linear ion trap. An additional benefit is the opportunity to further extend performance with an upgrade path to Thermo Scientific Orbitrap technology, offering ultra- high resolution, mass accuracy and increased dynamic range. For more information on this program please visit www. thermo. com/ tradeup Linear Ion Trap Trade- Up Program for Single Quadrupole and Ion Trap LC- MS Users

281 Cerno BioscienceandAgilent Technologiesannounce they will jointly market Cerno's MassWorks calibration software to Agilent GC/ MSD ChemStation users. This novel calibration increases the mass accuracy of Agilent's single quadrupole GC/ MSD sufficiently to identify unknown compounds. This normally requires use of much more expensive, larger instruments such as Quadrupole Time- of- Flight, or Fourier Transform Ion Resonance mass spectrometers. MassWorks for GC/ MSD uses Cerno's patented technology to calibrate raw MS data from Agilent's GC/ MSD using peak shape, followed by CLIP formula ID based on spectral accuracy. This technique dramatically improves mass accuracy and enables single- quad instruments to identify unknown compounds. In addition to enabling compound identification without a library, the formula ID function also speeds and adds confidence to library searches. The combined capabilities of the Agilent GC/ MSD Chemstation and Cerno's MassWorks means there is now an economic alternative to high-resolution GC/ MS systems for formula ID. " The combination of Agilent's GC/ MS with Cerno's MassWorks holds real value for end users," said Chris Toney, Agilent vice president and general manager, Mass Spec Systems. " Customers can use their workhorse single- quad instruments to identify unknowns rather than rely on more specialized instruments with associated costs and delays." For further informaton visit www. agilent. com or www. cernobioscience. com CBS 103, the latest edition of CAMAG's Bibliography Service, is available now from CAMAG's UK distributor, Omicron Research Limited. The lead article focuses on HPTLC as a fast and reliable method of detecting harmful, illegal dyes used in spice powders and mixes. Also featured is the pioneering work being carried out determining unknown plant extracts using planar chromatography. The use of some carcinogenic azo dyes, such as Sudan I, in spices to enhance their red and orange colouring is illegal. Since 2007, the State Laboratory in Zurich has been using HPTLC as a valuable tool in identifying these harmful dyes in such spices as chilli, paprika and curry powder. HPTLC is particularly suited to this type of analysis due to its rapid and matrix- robust screening of many samples in parallel, making it reliable and cost- effective. The advantages of HPTLC can also be applied to the screening of unknown plant extracts, a technique commonly used in cosmetic applications for identifying potential candidates for development of new cosmetic relevant compounds. High sample throughput results in short analysis times and low costs whilst the variety of derivatization reactions makes planar chromatography a powerful tool in this competitive field. Copies of CBS 103 are available, free of charge from Omicron on info@ omicron- uk. com or 01672 541425. Calibration Software Enables SingleHPTLCLeading The Way In Food Safety Quadrupole Instruments to Easily Identify Unknowns